Description

Celkeran 2 mg Tablets (Chlorambucil) – Cancer Chemotherapy Medication

Celkeran 2 mg contains Chlorambucil, an oral chemotherapy medication used to treat certain types of cancers, including leukemia and lymphoma. It belongs to the class of alkylating agents, which work by slowing or stopping the growth of cancer cells.

• Brand Name: Celkeran

• Generic Name: Chlorambucil

• Strength: 2 mg per tablet

• Form: Oral tablet

• Manufacturer: Celon Laboratories Ltd / Natco Pharma (or other regional manufacturers)

• Prescription Required: ✔ Yes

• ATC Classification: L01AA02

Therapeutic Indications

Celkeran 2 mg is prescribed for the treatment of:

• Chronic Lymphocytic Leukemia (CLL)

• Hodgkin’s Lymphoma

• Non-Hodgkin’s Lymphoma

• Waldenström’s Macroglobulinemia

• Other malignant lymphoid conditions, as determined by an oncologist

Mechanism of Action

Chlorambucil works by binding to DNA in cancer cells, preventing them from dividing and multiplying. This slows the spread of the disease and helps to control the growth of abnormal blood cells.

Dosage and Administration

• Dosage is highly individualized based on your condition, weight, and response to treatment.

• Generally taken once daily or in cyclical courses, with or without food.

• Swallow the tablets whole with water.

• Do not crush or chew.

• Handle tablets with care—wear gloves if needed.

Important: Treatment should only be started under strict medical supervision, preferably by an oncologist.

Warnings and Precautions

• Not suitable for pregnant or breastfeeding women unless deemed necessary by a doctor.

• Regular blood tests are required to monitor bone marrow function and liver enzymes.

• Avoid exposure to infections during treatment.

• Risk of secondary malignancies with long-term use.

• Use with caution in patients with liver or kidney impairment.

Possible Side Effects

Common side effects:

• Bone marrow suppression (low blood counts)

• Nausea, vomiting

• Fatigue

• Mouth sores

• Abdominal discomfort

Serious side effects (seek immediate medical attention):

• Fever or signs of infection

• Severe allergic reactions (rash, itching, swelling)

• Seizures (rare)

• Jaundice or liver function abnormalities

Storage

• Store at 2°C to 8°C (refrigerated).

• Keep out of reach of children.

• Do not use after the expiration date on the packaging.

• Store in original packaging to protect from moisture.

Frequently Asked Questions (FAQs) – Celkeran 2 mg (Chlorambucil)

1. What is Celkeran used for?

Celkeran 2 mg is used to treat blood cancers such as chronic lymphocytic leukemia, Hodgkin’s disease, and non-Hodgkin’s lymphoma.

2. How does Chlorambucil work?

It binds to DNA in cancer cells, disrupting their growth and reproduction.

3. Is Celkeran chemotherapy?

Yes, Chlorambucil is a chemotherapy agent from the alkylating group.

4. Can I take Celkeran at home?

Yes, it is an oral chemotherapy drug, but it should only be taken under strict medical guidance and supervision.

5. Does Celkeran have side effects?

Yes. Side effects can include low blood cell counts, nausea, fatigue, and in rare cases, secondary cancers. Regular monitoring is essential.

6. Is it safe to use during pregnancy?

No, Celkeran can harm the fetus. It should not be used during pregnancy unless absolutely necessary and prescribed by an oncologist.

7. Can it affect fertility?

Yes, like many chemotherapy agents, Chlorambucil may impact male and female fertility. Discuss fertility preservation options with your doctor.

8. Do I need to refrigerate Celkeran?

Yes. Store it between 2°C and 8°C in the refrigerator and keep it away from children.

9. How long will I need to take Celkeran?

Treatment duration depends on your response, type of cancer, and blood work results. Your doctor will determine the length of therapy.

10. Can I drink alcohol during treatment?

It is best to avoid alcohol, as it can increase liver toxicity and worsen side effects.