Flutamide 250 mg

Overview

Flutamide 250 mg is a non-steroidal anti-androgen medication used primarily in the treatment of **prostate cancer**. It works by blocking the action of androgens (male hormones) such as testosterone, which fuel the growth of prostate cancer cells. Flutamide is usually prescribed in combination with **luteinizing hormone-releasing hormone (LHRH) agonists** for advanced or metastatic prostate cancer treatment.

Key Details

• Generic Name: Flutamide
• Strength: 250 mg
• Form: Oral tablet
• Drug Class: Anti-androgen
• Primary Use: Advanced prostate cancer

How It Works

Flutamide competes with androgens like testosterone for binding to androgen receptors in prostate cells. By doing so, it **inhibits the stimulatory effects of testosterone on cancer growth**, slowing disease progression. It is most effective when used with other hormone-suppressing therapies.

Indications

• Advanced or metastatic prostate cancer
• In combination with LHRH agonists (e.g., leuprolide)
• Off-label: Hirsutism and hyperandrogenism in women (rare cases, under supervision)

Dosage & Administration

• Typical adult dose: 250 mg orally 3 times daily (every 8 hours)
• Start Flutamide therapy before or at the same time as LHRH agonist
• Take with food to reduce gastrointestinal upset
• Continue treatment as prescribed even if symptoms improve

Precautions

• Monitor liver function regularly (risk of hepatotoxicity)
• Not for use in women who are pregnant or may become pregnant
• Inform your doctor of any liver, kidney, or cardiovascular issues
• Not recommended for patients with severe hepatic impairment

Possible Side Effects

• Gynecomastia (breast enlargement in men)
• Hot flashes, fatigue, or decreased libido
• Diarrhea or gastrointestinal upset
• Liver toxicity (elevated liver enzymes or jaundice)
• Rare: Blood disorders, breathing difficulties

FAQs

Q1: What is Flutamide 250 mg used for?

A: It is used to treat advanced prostate cancer by blocking the effects of male hormones that stimulate cancer growth.

Q2: How quickly does it start working?

A: Hormonal suppression starts within days, but noticeable improvements in symptoms may take weeks.

Q3: Can Flutamide be used alone?

A: It is usually combined with LHRH agonists for better effectiveness. Rarely used alone due to limited efficacy.

Q4: What tests are required during treatment?

A: Liver function tests, PSA levels, and blood counts should be monitored regularly during treatment.

Q5: Is this medication safe for long-term use?

A: Long-term use is common in prostate cancer treatment, but liver monitoring is essential due to risk of hepatotoxicity.