Description

Celkeran 5 mg Tablets (Chlorambucil) – Chemotherapy for Blood Cancers

Celkeran 5 mg is an oral chemotherapy medication containing Chlorambucil, a nitrogen mustard alkylating agent. It is commonly prescribed for the treatment of chronic lymphocytic leukemia (CLL), Hodgkin’s lymphoma, and non-Hodgkin’s lymphoma. Celkeran works by interfering with the DNA replication in cancer cells, effectively slowing or stopping their growth.

• Generic Name: Chlorambucil

• Brand Name: Celkeran

• Strength: 5 mg per tablet

• Form: Oral tablet

• Manufacturer: Natco Pharma / Celon Labs (or other licensed producers)

• Prescription Required: ✔ Yes

• Storage Requirement: Refrigeration (2°C to 8°C)

Therapeutic Uses

Celkeran 5 mg is prescribed for:

• Chronic Lymphocytic Leukemia (CLL)

• Hodgkin’s Disease (Hodgkin’s Lymphoma)

• Non-Hodgkin’s Lymphoma

• Waldenström’s Macroglobulinemia

• Other lymphoproliferative disorders under oncologist supervision

Mechanism of Action

Chlorambucil is an alkylating agent that binds to DNA and prevents cancer cells from dividing and multiplying. This reduces the number of abnormal white blood cells in conditions like leukemia and lymphomas.

Dosage & Administration

• Dosage is individualized by a healthcare professional based on disease type, weight, age, and response.

• Usually taken once daily or in treatment cycles.

• Tablets should be swallowed whole with water.

• Do not chew or crush the tablets.

• Handle tablets with care; avoid direct contact with skin.

💡 Regular blood monitoring is necessary during treatment.

Precautions

• Avoid during pregnancy and breastfeeding unless explicitly directed by a specialist.

• Patients must be monitored for bone marrow suppression and liver function.

• Inform your doctor if you have liver disease, recent infections, or seizures.

• Increased risk of secondary cancers (e.g., acute leukemia) with long-term use.

Possible Side Effects

Common:

• Nausea

• Vomiting

• Fatigue

• Loss of appetite

• Bone marrow suppression (anemia, low WBC/platelets)

Serious (seek immediate attention):

• Fever or infection symptoms

• Unusual bruising or bleeding

• Seizures (rare)

• Liver dysfunction or jaundice

• Severe allergic reaction

Storage

• Refrigerate at 2°C to 8°C

• Keep in original packaging

• Do not expose to direct sunlight or moisture

• Keep out of reach of children

Frequently Asked Questions (FAQs) – Celkeran 5 mg (Chlorambucil)

1. What is Celkeran 5 mg used for?

It’s used to treat blood cancers such as chronic lymphocytic leukemia, Hodgkin’s lymphoma, and non-Hodgkin’s lymphoma.

2. Is Celkeran chemotherapy?

Yes. Celkeran is an oral chemotherapy drug in the alkylating agent class.

3. How is Celkeran 5 mg taken?

Usually once daily with or without food, or in cycles based on your doctor’s instructions. Swallow whole; do not crush or chew.

4. Can I take Celkeran at home?

Yes, but only under strict medical supervision. Follow dosage and handling instructions carefully.

5. What are the common side effects?

Nausea, fatigue, reduced blood counts, and vomiting. Serious effects include bone marrow suppression and liver issues.

6. Why is blood monitoring needed during treatment?

Because Celkeran can suppress bone marrow function, causing a drop in white blood cells, platelets, and red cells.

7. Should Celkeran be stored in the fridge?

Yes. Store it between 2°C and 8°C, and never freeze or expose it to heat.

8. Can Celkeran affect fertility?

Yes. It may affect both male and female fertility. Discuss fertility preservation options with your doctor before starting treatment.

9. Is Celkeran safe during pregnancy?

No. It is not recommended during pregnancy or breastfeeding due to the risk of fetal harm.

10. Can I drink alcohol while on Celkeran?

It’s best to avoid alcohol, as it can worsen liver-related side effects and increase fatigue.